Transcranial alternating current stimulation ameliorates emotional attention through neural oscillations modulation

Abstract Background Numerous clinical reports have suggested that psychopathy like schizophrenia, anxiety and depression is accompanied by early attentional abnormalities in emotional processing. Recently, the efficacy of transcranial alternating current stimulation (tACS) changing functioning has been repeatedly observed demonstrated a causal relationship between endogenous oscillations Aims Up to now, tACS effects on attention not yet tested. To assess such ability, we delivered active-tACS at individual alpha frequency (IAF), 10 Hz or sham-tACS for 7 consecutive days bilaterally dorsolateral prefrontal cortex (dlPFC) totally 79 healthy participants. Results IAF-tACS group showed significant entrainment at-rest, especially open state around area an obvious advantage compared Hz-tACS. Event-related potential revealed larger P200 amplitude after IAF wider range emotions than Hz-tACS, indicating improvement facial emotion A notable positive correlation power provided electrophysiological interpretation regarding role modulation instead somatosensory effects. Conclusion These results support seminal outcome effect modulation, demonstrating feasible individual-specific therapy neuropsychiatric disorders related processing, oscillatory disturbances.